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Retained Primitive Reflexes and Potential for Intervention in Autism Spectrum Disorders offers a bold developmental framework for understanding autism spectrum disorder through the lens of early sensorimotor organization, hemispheric maturation, and functional brain connectivity. Primitive reflexes are among the earliest expressions of nervous system activity. Normally, they support survival, movement, sensory exploration, and early interaction with the world before being progressively inhibited as cortical control, postural stability, and voluntary motor function emerge. When these reflexes persist beyond infancy, they may signal more than delayed motor maturation; they may reveal broader disruptions in developmental timing, neural integration, and brainstem-cortical regulation.

In this volume, Gerry Leisman and Robert John Melillo examine retained primitive reflexes as accessible markers of neurodevelopmental organization and as potential contributors to the motor, sensory, cognitive, behavioral, and social features associated with autism spectrum disorder. Moving across developmental neuroscience, clinical neurology, rehabilitation science, motor control, electrophysiology, and intervention research, the book situates reflex persistence within a larger systems model of autism as a condition involving altered hemispheric asymmetry, reduced long-range connectivity, increased local processing, and inefficient coordination among distributed neural networks.

The book advances a nuanced, testable, and clinically relevant hypothesis: that retained primitive reflexes may provide a window into maturational delay and neural inefficiency, and that carefully designed intervention may help improve timing, coordination, connectivity, and function in selected individuals. Written for clinicians, neuroscientists, therapists, educators, and researchers, this book invites a reconsideration of early motor development as a foundational pathway into brain organization, autism, and neurodevelopmental intervention. It is both a theoretical synthesis and practical challenge for future controlled research programs.