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商品詳細
Dose Finding and Beyond in Biopharmaceutical Development.
・ISBN 978-3-031-67112-8 paper EUR 159.99
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| 著者・編者 | Ye, Jingjing / Chen, Ding-Geng / Zhou, Wen / Deng, Qiqi / Cappelleri, Joseph C. (eds.), |
|---|---|
| シリーズ | ICSA Book Series in Statistics |
| 出版社 | (Springer International Publishing AG, SZ) |
| 出版年月 | 2025 |
| ページ数 | 254 pp. |
| 言語 | ENG |
| ニュース番号 | ＜M25-25454＞ |
解説
This book covers topics in 2 parts: 1) Review of FDA Guidance, 2) Novel Designs and Analyses. While covering basic principles of dose finding, this book details advancements made in drug development.
Finding the right dose(s) is one of the most important objectives in new drug development. In Phase I clinical development, one of the objectives is to escalate test doses from low to high. The low doses should be safe, then escalate up to the maximally tolerable dose (MTD). Phase ? clinical trials then lower test doses to the minimal efficacious dose (MinED). Dose range of a study drug can be thought of as the doses between MinED and MTD. From this dose range, one or a few doses are selected for Phase ? confirmation. In practice, dose finding is a very difficult in every phase of clinical development for new drugs.
The editors brought distinguished researchers and practitioners in biopharmaceuticals and universities, to discuss the statistical procedures, useful methods, and their novel applications in dose finding. The chapters in the book present emerging topics in dose-finding and related interdisciplinary areas. This timely book is a valuable resource to stimulate the development of this growing and exciting field in drug development.