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This book presents a multidisciplinary exploration of artificial intelligence, digital transformation, and sustainability across education, energy, healthcare, urban systems, governance, and socio-economic development. Besides environmental communication, the book examines the role of generative AI in enhancing the quality of higher education, critically assesses the conceptual foundations of artificial intelligence and investigate its application in optimizing green hydrogen production and carbon footprint prediction. Several contributions focus on AI-driven solutions in healthcare, including real-time ECG monitoring, prostate cancer classification, health information systems, and digital platforms for early childhood parenting education. The book also addresses AI adoption in humanitarian logistics, construction management, cybersecurity, and organizational performance, highlighting the mediating and moderating factors that influence successful implementation. Urban and regional perspectives are explored through smart cities, eco-districts, digital twins for mobility, and sustainable urban development models, alongside discussions on smart governance, public leadership, and regional transformation in the Mediterranean context. Collectively, the book provides theoretical insights, empirical evidence, and practical frameworks that demonstrate how AI and digital technologies can drive sustainable, inclusive, and resilient development across multiple sectors.