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This book proposes ecology of wisdom as a new field of study and interdisciplinary research, with Institutional Wisdom-in-Design at its core. It examines how Institutional Wisdom-in-Design can be identified, developed, and applied to transform global institutions, from schools and universities to research laboratories and international organizations. Through a methodologically structured exploration across a preface, an acknowledgement, an abstract, an introduction, fourteen chapters, and an epilogue, it introduces a unifying methodological framework to address new frontiers of institutional and interdisciplinary inquiry. Central themes in focus include an Institutional Copernican Revolution for academic and international bodies; the World-5 of Methodology of Wis-Design Improvement Science as a foundation for advancing moral progress in education, healthcare, and human rights; and Culture of Wisdom Inquiry driven science and technology to address global challenges. The volume develops a theory of Knowledge Resources Dynamics across the sciences and humanities, focused on human well-being interests in terms of Planetary Imperatives of Inclusive Sustainable Development. By linking Institutional Wisdom-in-Design with human well-being, it articulates a framework for rethinking the role of institutions in securing brighter prospects for humanity's future. Because ecological human well-being interests are seriously undermined by the unending race for competitive war-industries capable of proliferating "nuclear weapons bazaars" globally, it envisages a world-order which can free humanity from making new types of dangerous weapons, from investing in the proliferation of nuclear weapons, and from the looming totalitarian catastrophes such as a nuclear war.