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商品詳細
Molecular Dynamics and Optimization Studies of ?-Synuclein Protein Structures: Mechanism Underlying the Parkinson's Disease and Movement Disorders.
・ISBN 978-3-032-21280-1 hard EUR 179.99
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| 著者・編者 | Zhang, Jiapu, |
|---|---|
| シリーズ | (Springer Series in Biophysics) |
| 出版社 | (Springer Nature Switzerland AG, SZ) |
| 出版年月 | 2026 |
| ページ数 | 1861 pp. |
| 言語 | ENG |
| ニュース番号 | ＜A05-57796＞ |
解説
Parkinson's disease (PD), the second most common neurodegenerative disorder in human. The cause of PD is believed to involve genetic factors. At least 6 pathogenic genes have been associated with familial PD. ?-Synuclein (?S) is the main component of the Lewy bodies that accumulate in the brains of people with PD. Misfolding of the ?S protein has been implicated in the molecular chain of events leading to PD. This book studies wild type (WT) ?S proteins and their (8) ?S(1-140)-mutants by optimization and Molecular Dynamics (MD). In this book our systematic MD study of a wider range of mutants would provide some answers for genetic factors.
Numerous bindings of some segments of ?S are also MD studied. Some fibrils leaded by aS misfolding are MD studied too.
This book is particularly valuable for professionals working in computing roles within computational biochemistry/biophysics, bioinformatics, etc. It serves as an accessible introduction and is an excellent resource for students.