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Structure-based Drug Discovery. 2007 ed.
・ISBN 978-1-4020-4406-9 hard EUR 99.99
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| 著者・編者 | Jhoti, Harren / Leach, Andrew R. (eds.), |
|---|---|
| 出版社 | (Springer-Verlag New York Inc., US) |
| 出版年月 | 2007 |
| ページ数 | 250 pp. |
| 言語 | ENG |
| ニュース番号 | ＜A05-50655＞ |
解説
Structure-based drug discovery methods have been transformed in the last 5-10 years and are now having a major impact on the discovery of new drugs. Some of the most exciting developments in the field, such as Fragment-based methods, are described in this book.
The book describes the latest developments in technologies that can be used to obtain the 3-D structures including the high profile structural genomics approaches being utilised worldwide. The use of 3-D protein structures in new, Fragment-based, approaches to drug discovery are described in some detail. This book includes experimental approaches using X-ray crystallography and NMR for Fragment-based screening as well as other biophysical methods for studying protein/ligand interactions. In addition, developments in computational chemistry methodology are covered together with an assessment of practical applications.