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商品詳細
Histone Recognition. Softcover Reprint of the Original 1st 2015 ed.
・ISBN 978-3-319-37666-0 paper EUR 99.99
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| 著者・編者 | Zhou, Ming-Ming (ed.), |
|---|---|
| 出版社 | (Springer International Publishing AG, SZ) |
| 出版年月 | 2016 |
| ページ数 | 282 pp. |
| 言語 | ENG |
| ニュース番号 | ＜A05-49689＞ |
解説
This book provides a timely review of the role of histone modifications in epigenetic control of gene expression. Topics covered include: basic mechanisms of molecular recognition of histone post-translational modification (PTMs); combinatorial readout of histone PTMs by tandem epigenome reader domains; genome-wide profiling of histone PTM interactions; small molecule modulation of histone PTM interactions and their potential as a new approach to therapeutic intervention in human diseases. All chapters were written by leading scientists who made the original key discoveries of the structure and mechanism of evolutionarily conserved reader domains, which serve to direct gene transcription in chromatin through interactions with DNA-packing histones in a PTM-sensitive manner.