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Phenotypes and Genotypes: The Search for Influential Genes. 1st ed. 2016
・ISBN 978-1-4471-5309-2 hard EUR 99.99
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| 著者・編者 | Frommlet, Florian / Bogdan, Malgorzata / Ramsey, David, |
|---|---|
| シリーズ | (Computational Biology) |
| 出版社 | (Springer London Ltd, UK) |
| 出版年月 | 2016 |
| ページ数 | 222 pp. |
| 言語 | ENG |
| ニュース番号 | <A05-46193> |
解説
This timely text presents a comprehensive guide to genetic association, a new and rapidly expanding field that aims to elucidate how our genetic code (genotypes) influences the traits we possess (phenotypes). The book provides a detailed review of methods of gene mapping used in association with experimental crosses, as well as genome-wide association studies. Emphasis is placed on model selection procedures for analyzing data from large-scale genome scans based on specifically designed modifications of the Bayesian information criterion. Features: presents a thorough introduction to the theoretical background to studies of genetic association (both genetic and statistical); reviews the latest advances in the field; illustrates the properties of methods for mapping quantitative trait loci using computer simulations and the analysis of real data; discusses open challenges; includes an extensive statistical appendix as a reference for those who are not totally familiar with the fundamentals of statistics.