株式会社極東書店トップ ＞ 商品一覧 ＞ Reelin Glycoprotein: Structure, Biology and Roles in Health and Disease. 2008 ed.
商品詳細
Reelin Glycoprotein: Structure, Biology and Roles in Health and Disease. 2008 ed.
・ISBN 978-1-4899-8695-5 paper EUR 199.99
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| 著者・編者 | Fatemi, S.H. (ed.), |
|---|---|
| 出版社 | (Springer-Verlag New York Inc., US) |
| 出版年月 | 2014 |
| ページ数 | 443 pp. |
| 言語 | ENG |
| ニュース番号 | ＜A05-27075＞ |
解説
Reelin glycoprotein is a serine protease with important roles in embryogenesis and during adult life. Reelin mutations or deficiency of the protein product could cause abnormal cortical development and reelin signaling impairment in brain. Reelin abnormalities in several neurospychiatric disorders, such as autism, schizophrenia, mood disorders and lissencephaly, may provide mechanistic explanations for etiologies of these disorders. There is also emerging data indicating the feasibility of using various medications (valproic acid, olanzapine) to increase mRNA/protein levels for reelin and/or gene therapy to prevent or treat reelin deficiencies observed in the above-mentioned disorders.
This comprehensive and integrative book examines the role that reelin plays in the etiology of various neuropsychiatric disorders, including schizophrenia and autism.