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This volume explores the emerging understanding that severe burns may act as catalysts for neurodegenerative processes, resulting in long-term sensorimotor, cognitive, and functional decline. Burn-induced systemic inflammation, neuroinflammatory cascades, and ICU-related neurological syndromes collectively form a clinical continuum that mimics or contributes to neurodegeneration. Framed within this paradigm, this book offers an evidence-based approach to neuromotor rehabilitation that addresses both central and peripheral nervous system complications. It bridges acute trauma with chronic neurofunctional loss, positioning physical therapy as a pivotal intervention to modulate degeneration, support neuroplasticity, and enhance recovery.