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Translational health informatics is a rapidly evolving field, drawing insights from diverse disciplines like translational medicine, socio-technical systems thinking, and information systems design science. Its primary goal is to enhance the safety, quality, and outcomes of patient care through customer centered health informatics and ethical application of emerging technologies. The book emphasizes understanding the bigger picture, conducting perceptive value audits, and employing a diagnostic approach to identify sector-specific "wicked problems". It fosters synergy between clinical expertise and health informatics practices, highlighting multidisciplinary knowledge and rigorous quality assessment. This approach incorporates creative touch, visual clarity and intuitive user interfaces. The evolution of translational health informatics also highlights the need for advancements in education and expertise, extending also to the training curricula of healthcare professionals. This thought-provoking book is an informed read for health professionals and students, health informatics designers, institutions, and healthcare consumers eager to understand and contribute to the advancements within this critical sector.