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This open access book brings together an interdisciplinary group of scholars to examine how North American civil society organizations have actively mobilized within and across borders in response to the tumultuous social and economic changes in the region since the implementation of the North American Free Trade Agreement (NAFTA). Contributors from the three countries address the implications of recent changes in areas such trade, labour, migration and human rights. They draw on a rich and varied set of empirical case studies to detail the opportunities and constraints that activists have encountered as they navigate a changing landscape marked by the renegotiation of NAFTA, Trump's threats to build a US-Mexico border wall, the COVID-19 pandemic and continued restrictions on migration. The contributors highlight organizing strategies, the potential for new alliances and pose critical questions about the nature of transnational activism in the current conjuncture.