株式会社極東書店トップ ＞ 商品一覧 ＞ Transporters in Drug Development: Discovery, Optimization, Clinical Study and Regulation. 2013 ed.
商品詳細
Transporters in Drug Development: Discovery, Optimization, Clinical Study and Regulation. 2013 ed.
・ISBN 978-1-4614-8228-4 hard EUR 149.99
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| 著者・編者 | Sugiyama, Yuichi / Steffansen, Bente (eds.), |
|---|---|
| シリーズ | (AAPS Advances in the Pharmaceutical Sciences Series) |
| 出版社 | (Springer-Verlag New York Inc., US) |
| 出版年月 | 2013 |
| ページ数 | 317 pp. |
| 言語 | ENG |
| ニュース番号 | ＜A04-84104＞ |
解説
Transporters in Drug Development examines how membrane transporters can be dealt with in academic-industrial drug discovery and pharmaceutical development as well as from a regulatory perspective. The book describes methods and examples of in vitro characterization of single transporters in the intestines, liver and kidneys as well as characterization of substrate overlap between various transporters. Furthermore, probes and biomarkers are suggested for studies of the transporters' impact on the pharmacokinetics of drug substrates/candidates interacting on transporters. The challenges of translating in vitro observed interaction of transporters into in vivo relevance are explored, and the book highlights perspectives of applying targeted proteomics and mechanistic modeling in this process.