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A Network-Based Approach to Cell Metabolism: From Structure to Flux Balances. 1st ed. 2017
・ISBN 978-3-319-63999-4 hard EUR 99.99
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| 著者・編者 | Gueell, Oriol, |
|---|---|
| シリーズ | (Springer Theses) |
| 出版社 | (Springer International Publishing AG, SZ) |
| 出版年月 | 2017 |
| ページ数 | 151 pp. |
| 言語 | ENG |
| ニュース番号 | ＜A04-63299＞ |
解説
This thesis uses a systems-level approach to study the cellular metabolism, unveiling new mechanisms and responses that were impossible to reach with traditional reductionists procedures.
The results reported here have a potential application in areas like metabolic engineering and disease treatment. They could also be used in determining the accuracy of the gene essentiality of new genome-scale reconstructions.
Different methods and techniques, within the contexts of Systems Biology and the field known as Complex Networks Analysis have been applied in this work to show different features of the robustness of metabolic networks. The specific issues addressed here range from pure topological aspec
ts of the networks themselves to the balance of biochemical fluxes.