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This book opens up new perspectives on the relationship between art, medicine, and science in late-medieval and early modern Europe. Looking beyond the traditional nexus of art, anatomy, and optics, the volume sheds light on a broader array of connections between artists and physicians: collaborations between painters and doctors on colour charts, handwork skills common to sculptors and surgeons, the transmission of art theory through medical texts long before the emergence of art writing itself as an independent genre, and the kinship of medical diagnosis with early modes of connoisseurship. Reconfiguring the histories of art, medicine, and science, the book also traverses conventional boundaries between physical and mental health, religious and medical modes of healing, menial and exalted forms of knowledge and labour, as well as vernacular and scientific understandings of human difference, including gender, race, and neurodiversity.