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Declared Defective is the anthropological history of an outcaste community and a critical reevaluation of The Nam Family, written in 1912 by Arthur Estabrook and Charles Davenport, leaders of the early twentieth-century eugenics movement. Based on their investigations of an obscure rural enclave in upstate New York, the biologists were repulsed by the poverty and behavior of the people in Nam Hollow. They claimed that their alleged indolence, feeble-mindedness, licentiousness, alcoholism, and criminality were biologically inherited.

Declared Defective reveals that Nam Hollow was actually a community of marginalized, mixed-race Native Americans, the Van Guilders, adapting to scarce resources during an era of tumultuous political and economic change. Their Mohican ancestors had lost lands and been displaced from the frontiers of colonial expansion in western Massachusetts in the late eighteenth century. Estabrook and Davenport's portrait of innate degeneracy was a grotesque mischaracterization based on class prejudice and ignorance of the history and hybridic subculture of the people of Guilder Hollow. By bringing historical experience, agency, and cultural process to the forefront of analysis, Declared Defective illuminates the real lives and struggles of the Mohican Van Guilders. It also exposes the pseudoscientific zealotry and fearmongering of Progressive Era eugenics while exploring the contradictions of race and class in America.