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The Oxford Handbook of Healthcare Innovation bridges theory and practice of mainstream innovation studies as applied in the healthcare sector, offering valuable resources to professionals, policymakers, and researchers who are dedicated to addressing the complexities of modern healthcare. It advances the latest developments in healthcare innovation research and practice and, with its global emphasis, draws from research and case studies from both high-income as well as low and middle-income countries. The diverse selection of topics covered in the chapters are categorized into three parts reflective broadly of the innovation process: development, diffusion, and evaluation and governance. With over fifty contributors, a range of twenty-seven topics are explored, from frugal, reverse, disruptive and open innovation, to knowledge brokerage, epistemic communities, decolonization, and change management. Within each chapter, contributors discuss the state-of-the-debate in their domain of expertise at three levels of analysis -- micro, meso, and macro -- and with respect to the organizational, social, and technological aspects of healthcare.