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Frontier technologies, in particular AI, bring about profound ramifications in the way the economy and societies work. This disruptive change, coupled with the accelerating pace at which new technologies emerge and the global dimension reached by their diffusion and effects, make policymakers struggle to navigate and design responsive Science, Technology and Innovation (STI) policies. The TIR2025 report will analyze, especially from the perspective of developing countries, the socio-economic implications of the technological shift lead by frontier technologies with a focus on AI. The report will discuss and draw implications on AI policies, as well as the international actions needed to guarantee that technological progress will benefit all.