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Transmutation operators in differential equations and spectral theory can be used to reveal the relations between different problems, and often make it possible to transform difficult problems into easier ones. Accordingly, they represent an important mathematical tool in the theory of inverse and scattering problems, of ordinary and partial differential equations, integral transforms and equations, special functions, harmonic analysis, potential theory, and generalized analytic functions. This volume explores recent advances in the construction and applications of transmutation operators, while also sharing some interesting historical notes on the subject.