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These essays throw new light on the complex relations between science, literature and rhetoric as avenues to discovery in the seventeenth and eighteenth centuries. Scholars from a variety of disciplinary backgrounds examine the agency of early modern poets, playwrights, essayists, philosophers, natural philosophers and artists in remaking their culture and reforming ideas about human understanding. Analyzing the ways in which the works of such diverse writers as Shakespeare, Bacon, Hobbes, Milton, Cavendish, Boyle, Pope and Behn related to contemporary epistemological debates, these essays move us toward a better understanding of interactions between the sciences and the humanities during a seminal phase in the emergence of modern Western thought.