株式会社極東書店トップ ＞ 商品一覧 ＞ Decoding the Antibody Repertoire: High Throughput Sequencing of Multiple Transcripts from Single B Cells. 1st ed. 2017
商品詳細
Decoding the Antibody Repertoire: High Throughput Sequencing of Multiple Transcripts from Single B Cells. 1st ed. 2017
・ISBN 978-3-319-58517-8 hard EUR 99.99
￥26,726.- (税込) ※（※）価格はご注文時の参考価格となります。
納品価格につきましては書籍の入荷時点で確定となります。
版元の原価改定、外国為替の変動等により異なる場合がございますので、予めご了承下さい。
| 著者・編者 | DeKosky, Brandon, |
|---|---|
| シリーズ | (Springer Theses) |
| 出版社 | (Springer International Publishing AG, SZ) |
| 出版年月 | 2017 |
| ページ数 | 87 pp. |
| 言語 | ENG |
| ニュース番号 | ＜A03-39022＞ |
解説
This thesis outlines the development of the very first technology for high-throughput analysis of paired heavy and light-chain antibody sequences, opening an entirely new window for antibody discovery and the investigation of adaptive immune responses to vaccines and diseases.
Previous methods for high-throughput immune repertoire sequencing have been unable to provide information on the identity of immune receptor pairs encoded by individual B or T lymphocytes. The author directly addresses these limitations by designing two new technologies for sequencing multiple mRNA transcripts from up to 10 million isolated, single cells.
The techniques developed in this work have enabled comprehensive interrogation of human B-cell repertoires and have been applied for rapid discovery of new human antibodies, to gain new insights into the development of human antibody repertoires, and for analysis of human immune responses to vaccination and disease.