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Knowing how to prepare, write and publish high-quality research papers can be challenging for scientists at all stages of their career. This manual guides readers through successfully framing and presenting research findings, as well as the processes involved in publishing in learned journals. It draws on the author's wealth of practical experience, from working in academic research for over 40 years and teaching scientific writing in over 20 countries, to gaining insights as a journal editor. Well-written and logical, it provides clear step-by-step instructions to enable readers to become more effective at writing articles, and navigating difficulties related to journal submission, the review process, editing and publication. It comprehensively covers themes such as publication ethics, along with current topics including Open Access publishing and pre-print servers. This is a useful, user-friendly guide for graduate students, early career scientists, and more experienced researchers, particularly in the life and medical sciences.