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Formulating Poorly Water Soluble Drugs. Softcover reprint of the original 2nd ed. 2016
・ISBN 978-3-319-82618-9 paper EUR 164.99
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| 著者・編者 | Williams III, Robert O. / Watts, Alan B. / Miller, Dave A. (eds.), |
|---|---|
| シリーズ | (AAPS Advances in the Pharmaceutical Sciences Series 22) |
| 出版社 | (Springer International Publishing AG, SZ) |
| 出版年月 | 2018 |
| ページ数 | 779 pp. |
| 言語 | ENG |
| ニュース番号 | ＜A02-84020＞ |
解説
The objective of this volume is to consolidate within a single text the most current knowledge, practical methods, and regulatory considerations pertaining to formulations development with poorly water-soluble molecules. A pharmaceutical scientist's approach toward solubility enhancement of a poorly water-soluble molecule typically includes detailed characterization of the compound's physiochemical properties, solid-state modifications, advanced formulation design, non-conventional process technologies, advanced analytical characterization, and specialized product performance analysis techniques. The scientist must also be aware of the unique regulatory considerations pertaining to the non-conventional approaches often utilized for poorly water-soluble drugs. One faced with the challenge of developing a drug product from a poorly soluble compound must possess at minimum a working knowledge of each of the abovementioned facets and detailed knowledge of most. In light of the magnitude of the growing solubility problem to drug development, this is a significant burden especially when considering that knowledge in most of these areas is relatively new and continues to develop