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This volume celebrates the centenary of the birth of Elizabeth Anscombe, Philippa Foot, Mary Midgley and Iris Murdoch. These four remarkable women were philosophical colleagues in Oxford in the 1940s, and their careers intertwined and overlapped henceforth. The papers in this book are all by prominent philosophers who spoke at the Royal Institute of Philosophy's annual lecture series from 2018-9. Together they cover the philosophical careers of Anscombe, Foot, Midgley and Murdoch, focusing on their thinking on morality, human nature and action and the place of humanity in the animal and natural world, all areas to which they made notable and distinctive contributions. Connexions are drawn to the thought of Wittgenstein, Aquinas and Aristotle. This book demonstrates the way these four philosophers individually and collectively changed the direction of philosophy in the English speaking world in the mid-twentieth-century and how they continue to influence it one hundred years after their birth.