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Progress in the Chemistry of Organic Natural Products 115. 2021 ed.
・ISBN 978-3-030-64855-8 paper EUR 279.99
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| 著者・編者 | Kinghorn, A. Douglas / Falk, Heinz / Gibbons, Simon / Asakawa, Yoshinori / Liu, Ji-Kai / Dirsch, Verena M. (eds.), |
|---|---|
| シリーズ | (Progress in the Chemistry of Organic Natural Products) |
| 出版社 | (Springer Nature Switzerland AG, SZ) |
| 出版年月 | 2022 |
| ページ数 | 203 pp. |
| 言語 | ENG |
| ニュース番号 | ＜A02-51954＞ |
解説
This book describes current understandings and recent progress into a varied group of natural products. In the first chapter the role that total synthesis may play in revising the structures proposed for decanolides, which are ten-membered lactones found primarily in fungi, frogs, and termites is presented. The following chapter presents the development of the intriguing plant-derived sesquiterpene lactone, thapsigargin, a potent inhibitor of the enzyme, SERCA (sarco-endoplasmic Ca2+ ATPase), which has potential as a lead compound to treat cancer. The third chapter covers the potential of various plant phenolic compounds for treating the tropical and sub-tropical infectious disease, leishmaniasis. In addition the volume presents recent advances related to the plant alkaloid, cryptolepine, which is of particular interest as a lead for the treatment of malaria, trypanosomiasis, and cancer.