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In health and medicine, imagining the future is essential in giving meaning to the past and the present and for propelling people into action. This is true not only at the level of individuals as they envision and carry out everyday activities and long-term plans but also for institutional practices framed by and unfolding within various socio-political ecologies and transfigurations. Hope and uncertainty are critical affective and knowledge-related modalities of such imaginations and assume vital meanings in policing, managing, and experiencing health, illness, and well-being. This volume brings together contributions from medical anthropologists who address this theme across various medical spheres, including the pragmatics of hope and uncertainty, the techno-sphere, health management, and individual and socially distributed emotions.