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商品詳細
Sigma Receptors: Their Role in Disease and as Therapeutic Targets. Softcover reprint of the original 1st ed. 2017
・ISBN 978-3-319-84335-3 paper EUR 169.99
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| 著者・編者 | Smith, Sylvia B. / Su, Tsung-Ping (eds.), |
|---|---|
| シリーズ | (Advances in Experimental Medicine and Biology) |
| 出版社 | (Springer International Publishing AG, SZ) |
| 出版年月 | 2018 |
| ページ数 | 312 pp. |
| 言語 | ENG |
| ニュース番号 | ＜A02-17826＞ |
解説
Originally confused with opioid receptors and then orphan receptors with no biological function, Sigma Receptors are now recognized as relevant to many degenerative diseases with remarkable potential as therapeutic targets. In this text, new information about the structure of sigma 1 receptor, its binding sites are provided as well as its expression in many cell types. It's putative role in degenerative neuronal diseases including amyotrophic lateral sclerosis, Alzheimer's disease, Parkinson's disease, Huntington's disease, pain, drug addiction and locomotor activity. Their roles in possible treatments for blinding retinal diseases emphasize the tremendous far-reaching potential for ligands for these receptors. Exciting breakthroughs in this dynamic field in the last decade are reported herein, which will guide future investigators in determining the full potential of this unique, yet abundantly expressed protein.