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Cancer through the Lens of Evolution and Ecology.
・ISBN 978-1-032-31078-7 hard GB£ 171.99
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| 著者・編者 | Somarelli, Jason A. / Johnson, Norman A. (eds.), |
|---|---|
| 出版社 | (CRC Press, UK) |
| 出版年月 | 2024 |
| ページ数 | 194 pp. |
| 言語 | ENG |
| ニュース番号 | ＜A02-10550＞ |
解説
Cancer cells exist in an ever-changing "ecology" and are subject to evolutionary pressures just like any species in nature. This edited book explores the following themes: 1) how the dynamics of mutation, epigenetics, and gene expression noise are sources of genetic diversity; 2) how scarce resources influence cancer therapy resistance; 3) how predator-prey dynamics are mirrored in immune-cancer cross-talk; 4) how cancer cells parallel niche construction theory; 5) how changing fitness landscapes enable cancer growth; and 6) how cancer cells interact within the body. The book is a resource for understanding cancer as a disease of multicellularity grounded in evolutionary principles. By using this knowledge, researchers are starting to exploit these behaviors for treatment paradigms.
Key Features
- Bridges disciplines exemplifying the ways disparate fields create new perspectives when integrated.
- Offers insights from leading scholars in cancer biology, ecology and evolutionary biology.
- Provides a timely recognition by oncologists that evolutionary paradigms are crucial for breakthroughs in cancer treatment.
- Integrates basic and applied sciences of oncology and evolutionary biology.