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This book introduces the field of artificial intelligence in medicine, a new research area that combines sophisticated representational and computing techniques with the insights of expert physicians to produce tools for improving health care. An introductory chapter describes the historical and technical foundations of the work and provides an overview of the current state of the art and research directions. The authors then describe four prototype computer programs that tackle difficult clinical problems in a manner similar to that of an expert physician. The programs presented are internist, a diagnostic aid that combines a large database of disease/manifestation associations with techniques for problem formulation; expert and the Glaucoma Program which use physiological models for the diagnosis and treatment of eye disease; mycin, a rule-based program for diagnosis and therapy selection for infectious diseases; and the Digitalis Therapy Advisor, which aids the physician in prescribing the right dose of the drug digitalis and also explains its actions.