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Gene Regulation and Therapeutics for Cancer.
・ISBN 978-1-138-71242-3 hard GB£ 210.00
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| 著者・編者 | Batra, Surinder K. / Palanimuthu Ponnusamy, Moorthy (eds.), |
|---|---|
| 出版社 | (CRC Press, UK) |
| 出版年月 | 2021 |
| ページ数 | 322 pp. |
| 言語 | ENG |
| ニュース番号 | ＜A00-40255＞ |
解説
Differential gene regulation and targeted therapy are the critical aspects of several cancers. This book covers specific gene regulation and targeted therapies in different malignancies. It offers a comprehensive assessment of the transcriptional dysregulation in cancer, and considers some examples of transcriptional regulators as definitive oncogenic drivers in solid tumors, followed by a brief discussion of transcriptional effectors of the programs they drive, and discusses its specific targets. Most targeted therapeutics developed to date have been directed against a limited set of oncogenic drivers, exemplified by those encoding cell surface or cytoplasmic kinases that function in intracellular signaling cascades.