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Clinical Trials of Genetic Therapy with Antisense DNA and DNA Vectors.

Clinical Trials of Genetic Therapy with Antisense DNA and DNA Vectors.

・ISBN 978-0-8247-0085-0 hard GB£ 520.00

￥164,736.- (税込) ※（※）価格はご注文時の参考価格となります。
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電子版あり 大学・学術機関向け電子ブック（eBook）ISBN 9781003064657

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著者・編者Wickstrom, Eric (ed.),
出版社 (CRC Press Inc, US)
出版年月1998
ページ数448 pp.
言語ENG
ニュース番号＜A00-35051＞

解説

An important new collection of clinical and preclinical reports on genetic therapy, this book describes illustrative examples of diseases in which gene-based interventions are presently plausible, and presents case studies of current research using both synthetic oligonucleotides and biological vectors.
Combining the insights of over 50 contributors, Clinical Trials of Genetic Therapy with Antisense DNA and DNA Vectors

  • furnishes a historical overview of genetic therapy
  • highlights official Food and Drug Administration positions on the preparation of oligonucleotides and vectors
  • offers practical models of agent preparation, animal testing, pharmacokinetics, toxicology, and clinical trials
  • discusses both synthetic DNA and biological vector approaches to cancer, viral, and cardiological indications
  • illustrates for new practitioners how each stage of genetic therapy is developed
  • details genetic treatment of leukemia; lymphoma; cancer of the brain, breast, colon, kidney, and lung; melanoma; HIV; and coronary restenosis
  • includes examples of antisense, ribozyme, tumor suppressor, immunostimulation, and gene replacement therapy
  • and addresses questions of preparation, delivery, toxicity, mechanism, and specificity.