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For more than four decades, scientists and researchers have relied on the Advances in Chromatography series for the most up-to-date information on a wide range of developments in chromatographic methods and applications. Volume 45 of this authoritative series once again compiles the work of expert contributors in order to present timely and cutting-edge reviews on a variety of related topics. This volume focuses on applying various chromatographic techniques to combinatorial methods and high-throughput analyses. The authors address various limitations to traditional techniques and present developments that enable scientists to analyze a higher volume of smaller molecules under high-throughput conditions more efficiently. Other practical topics include discussions of selection criteria for using alternative solvents and reagents, minimum requirements for utilizing readily available instrumentation and methods for new applications, the use of high-throughput purification for obtaining higher quality leads, and new chromatographic data on organic endocrine disrupters. Advances in Chromatography: Volume 45 provides a good starting point to gain quick and up-to-date knowledge of the field and its most recent developments. Each author's clear presentation of topics and vivid illustrations make the material accessible and engaging to a variety of chemists with different levels of technical skill.