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Ribosome-inactivating Proteins: Ricin and Related Proteins.
・ISBN 978-1-118-12565-6 hard US$ 150.75
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| 著者・編者 | Stirpe, Fiorenzo / Lappi, Douglas (eds.), |
|---|---|
| 出版社 | (Wiley-Blackwell, UK) |
| 出版年月 | 2014 |
| ページ数 | 328 pp. |
| 言語 | ENG |
| ニュース番号 | ＜A00-18314＞ |
解説
This important reference provides up-to-date information on all aspects of ribosome-inactivating proteins (RIPs). Including a list of all known RIPs, their distribution in nature, structure, genetics and chemical and immunological properties, this reference covers mechanisms of action, including the enzymatic activity on various polynucleotide substrates; the interaction with, and entry into cells; the toxicity to animals, including the pathology of poisoning; and the immunomodulatory and allergenic activity. The book further emphasizes the use of immunotoxins and other conjugates in clinical trials for the therapy of cancer and intractable pain.