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How can systems-thinking contribute to solving key challenges in Global Health? Global Health is an evolving field operating within a complex interaction of political, environmental, economic, and socio-cultural factors. Any work on the subject needs to reflect current developments and be supported by a collaborative, interdisciplinary approach that retains a focus on the underpinning determinants of health. This book reflects the importance of applying a systems-thinking approach to Global Health challenges: one that examines both the individual elements within the system as well as the interrelationships between them and wider contextual patterns. Bringing together a global and multidisciplinary team of experts, this volume outlines the core concepts of a systems-thinking approach and how they can be applied to current Global Health problems. It provides a comprehensive range of case studies, reflections, conceptual pieces, and methodological approaches. Readers are invited to engage with arguments and assumptions across global health interventions and to connect systems-thinking theory with lived experiences. Well-established topics such as infectious and non-communicable diseases, as well as lesser-discussed areas such as still birth, mental health, and war and conflict are united under a shared systems-thinking framework. Offering innovative perspectives on current health challenges, students, academics, practitioners, and policy makers will find this a significant resource to enhance their understanding and application of systems-thinking in Global Health.