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Digitization is transforming our world economically, culturally and psychologically. The influx of new forms of communication, networking, and business opportunities, as well as new types of distraction, self-observation, and control into our societies represents an epochal challenge. Following Bernard Stiegler's concept of pharmacology, Felix Heidenreich and Florian Weber-Stein propose to view these new forms as digital pharmaka. Properly dosed, they can enable new self-relationships and forms of sociality; in the case of overdose, however, there is a risk of intoxication. In this essay, Felix Heidenreich, Florian Weber-Stein and, in a detailed interview, Bernard Stiegler analyze this complex change in our world and develop new skills to use digital pharmaka.