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Over the last three decades cross-border innovation has profoundly changed. The fragmentation of global value chains, increased global connectedness, and pervasive digitalization have helped shape innovation processes that now increasingly span national borders. This changing process has involved a wide array of actors (players) in a variety of geographical locations and organizational spaces (places), calling for new guidelines, public interventions, and regulatory frameworks (policies). Considering this complexity, the existing literature has only partially captured the ongoing changes in cross-border innovation and showed a limited engagement in integrative, cross-disciplinary debate. This book presents complementary and novel perspectives on the phenomenon from distinguished scholars, bridging perspectives from a rich set of research streams including international business, strategy, innovation studies and policy, international economics, industrial organization, economic geography, ethics, and sustainability. Three distinct sections focus on the players, the places, and the policies in contemporary cross-border innovation. Together, the contributions highlight the changing role of multinational enterprises and the growing participation of emerging actors in cross-border innovation, via formal and informal networks which are increasingly shaped around highly mobile individuals and new geographical centres. The book also emphasizes the intertwined role of policies at national and international level, stressing the importance of supply- and demand-oriented policies and presenting intellectual property right policies as a double-edged sword for cross-border innovation.