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Drawing on a wide range of sources including interdiction procedures, records of criminal justice, documentation from mental hospitals, and medical literature, this book provides a comprehensive study of the spaces in which madness was recorded in Tuscany during the eighteenth century. It proposes the notion of itineraries of madness, which, intended as an heuristic device, enables us to examine records of madness across the different spaces where it was disclosed, casting light on the connections between how madness was understood and experienced, the language employed to describe it, and public and private responses devised to cope with it. Placing the emotional experience of the Tuscan families at the core of its analysis, this book stresses the central role of families in the shaping of new understandings of madness and how lay notions interacted with legal and medical knowledge. It argues that perceptions of madness in the eighteenth century were closely connected to new cultural concerns regarding family relationships and family roles, which resulted in a shift in the meanings of and attitudes to mental disturbances.