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The volume focuses on the application of Peirce’s semeiotic as a methodological tool to establish a common field for interdisciplinary research. Contributors from the fields of biology, architecture, logic, esthetics and neuroscience, among others, work on diverse research problems, unified by the idea of transcending the dyadic limitations of disciplinary restrictions and applying Peirce’s triadic method, and the structure and process of sign relations of the particular problem that has to be solved. The result is an invigorating example of methodological plasticity wherein the reader acquires an understanding of scientific observation within the complex universe of semeiosis relations.