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This book, in the form of a classical philosophical treatise, presents a large-scale theoretical project: It uses a metaphilosophical perspective to present the framework for postmetaphysical thinking, situating it in the domain of the metaphysics of morality. It offers an innovative defence of scepticism based on a critical and radical analysis of the concepts of knowledge and truth. Metaphysical and transcendental traditions are deconstructed, mainly in relation to the paradoxes of so-called realism and idealism, which are the consequence of dependence on an archaic substance theory. Moreover, the book proposes a certain form of philosophising in spite of everything, i.e. within a sceptical approach. The critique of ethics leads to an a-ethical concept of the will and the values of life.