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In light of the current economic difficulties facing traditional development partners and the non-sustainable and non-inclusive nature of performance of the Least Developed Countries (LDCs) over the last decade, LDC governments need new development paths to tap into dynamic growth poles in the South. This publication explores the role of South-South cooperation and regional developmentalism, and finds that, in order to benefit from evolving South-South relations, LDCs need to transform into Catalytic Development States that are highly sensitive to LDC vulnerabilities and offer new policy agendas.