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Society and contemporary culture unquestionably assign much importance to the search for quality. So can this kind of research include the mind? In his analysis, Luigi Longhin examines the causes of mental illness and psychic-mental suffering, the notions of individuality, social violence, and utopia; and he suggests a collaboration between the neurosciences and psychoanalysis, within a correct epistemological approach. The relationship between epistemology and psychoanalysis is examined. The objectivistic and relativistic shift in contemporary epistemology, and the problem of the responsibility of the techno-scientific system are emphasized. Why such a privileged connection with philosophy? The contribution of philosophy is primarily epistemological. However, both epistemology and psychoanalysis run a risk; whilst epistemology runs the risk of being a knowledge which does not know, psychoanalysts run the risk of pursuing scientific knowledge without knowing its foundations. Hence there is a need for collaboration between the two forms of knowledge: the philosophical-epistemological and the scientific-psychoanalytic. Psychoanalysis works in two directions: on the one hand, it tries to eliminate the negative components of the mind, on the other hand, it tries to develop the trusting and creative parts of the self.