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Through an in-depth examination of the interactions between the South African government and the international AIDS control regime, Jeremy Youde examines not only the emergence of an epistemic community but also the development of a counter-epistemic community offering fundamentally different understandings of AIDS and radically different policy prescriptions. In addition, individuals have become influential in the crafting of the South African government's AIDS policies, despite universal condemnation from the international scientific community. This study highlights the relevance and importance of Africa to international affairs. The actions of African states call into question many of our basic assumptions and challenge us to refine our analytical framework. It is ideally suited to scholars interested in African studies, international organizations, global governance and infectious diseases.