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Europe and her regions - in particular the regions of East and Central Europe - witness tremendous change in all spheres of life. Although there is no order without border, borders are in a process of functional differentiation, both at the sub- and supra-national level. There are many more borders becoming, however, less consequential, no longer exclusive, but inclusive. All the challenges from globalisation, fragmentation, enlargement or integration not only surpass the potential of single regions or even nations, but need normative guide-lines and consistent incentive structures. In short: institutions do matter! But, what kind of institutions, at what level and designed for what purpose? This book with its multi-disciplinary approach from the perspective of international and constitutional law as well as economics tries to give answers to the prospective problems of managing complexity and flexibility for a future post-national Europe of regions.