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A scholarly examination of the centrality of the mind-body problem within and across the science of cognition-from philosophy to psychology to artificial intelligence to neural science. Conceptions of the mind-body problem range from the heritage of Cartesianism to the identification of the circumscribed brain structures responsible for domain specific cognitive mechanisms. Neither narrowly technical nor philosophically vague, this is a structured and detailed account of advancing intellectual developments in theory, research, and knowledge illumined by the conceptual vicissitudes of the mind-body problem. This unique treatment will be of special interest to creative scholars in the disciplines of he sciences of cognition.