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The systems of innovation approach is considered by many to be a useful analytical approach for better understanding innovation processes as well as the production and distribution of knowledge in the economy. It is an appropriate framework for the empirical study of innovations in their contexts and is relevant for policy makers. This text is the result of the work within an international inter-disciplinary network or working seminar with the task of building a more solid and sophisticated conceptual and theoretical foundation for the continued study of innovations in a systemic context. The book has three parts. The first presents an overview and tries to work out some conceptual problems. In the second, the systems of innovation approach is related to innovation theory. Part three is devoted to increasing understanding of the functioning and dynamics of systems of innovation. There is also an introduction where the genesis and anatomy of different systems of innovation approaches are discussed and where the systems of innovation approach is characterized in nine dimensions.